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2009\u5e74\u7684\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u670d\u7528\u6297\u6291\u90c1\u836f\u5e15\u7f57\u897f\u6c40\uff08paroxetine\uff09\u7684\u7537\u6027\u7684\u7cbe\u5b50\u53d1\u751f DNA \u788e\u7247\u5316\u7684\u53ef\u80fd\u6027\u4e3a\u666e\u901a\u7537\u6027\u76845\u500d\uff0c\u8fd9\u6837\u7684\u7cbe\u5b50\u66f4\u5bb9\u6613\u5bfc\u81f4\u6d41\u4ea7\u3002\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u4f5c\u8005\uff0c\u5eb7\u5948\u5c14\u5927\u5b66\u7684\u6ccc\u5c3f\u5b66\u5bb6 Peter Schlegel \u8868\u793a\uff1a\u670d\u836f\u7537\u6027\u7684\u201c\u7cbe\u5b50\u5728\u901a\u8fc7\u4eba\u4f53\u65f6\u53d1\u751f\u4e86\u5f02\u5e38\uff0c\u56e0\u6b64\u635f\u574f\u4e86\u3002\u201d<\/p>\n \u7238\u7238\u7684\u80d6\u7626\u4e5f\u4f1a\u5f71\u54cd\u540e\u4ee3<\/strong><\/p>\n \u5373\u4f7f\u4e0d\u548c\u6709\u5bb3\u5316\u5b66\u54c1\u63a5\u89e6\uff0c\u7238\u7238\u4eec\u7684\u4e0d\u826f\u751f\u6d3b\u4e60\u60ef\u4e5f\u4f1a\u70d9\u5370\u5728\u5b83\u4eec\u7684\u7cbe\u5b50\u91cc\u3002<\/p>\n \u8bb8\u591a\u52a8\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u4ea4\u914d\u524d\u7ecf\u5386\u98df\u7269\u5265\u593a\u7684\u5c0f\u9f20\u7236\u4eb2\u7684\u540e\u4ee3\u7684\u8840\u7cd6\u6c34\u5e73\u66f4\u4f4e\u3002\u5927\u9f20\u7236\u4eb2\u5982\u679c\u996e\u7528\u9152\u7cbe\uff0c\u90a3\u4e48\u540e\u4ee3\u51fa\u751f\u65f6\u4f53\u91cd\u66f4\u4f4e\uff0c\u5728\u8ff7\u5bab\u91cc\u7684\u7a7a\u95f4\u5b66\u4e60\u80fd\u529b\u66f4\u5dee\u3002<\/p>\n \u800c\u5438\u70df\u7684\u4eba\u7c7b\u7684\u7cbe\u5b50\u67d3\u8272\u4f53\u6570\u91cf\u66f4\u5bb9\u6613\u53d1\u751f\u5f02\u5e38\uff0c\u8fd9\u5bb9\u6613\u5bfc\u81f4\u6d41\u4ea7\u6216\u5510\u6c0f\u7efc\u5408\u5f81\u3002<\/p>\n \u540c\u6837\uff0c\u7238\u7238\u7684\u4f53\u91cd\u4e5f\u4f1a\u5f71\u54cd\u5b69\u5b50\u7684\u5065\u5eb7\u3002<\/p>\n \u7f8e\u56fd\u5987\u4ea7\u79d1\u533b\u5e08\u5b66\u4f1a\uff08ACOG\uff09\u4e3b\u5e2d\uff0c\u675c\u514b\u5927\u5b66\u533b\u5b66\u9662\u7684\u4ea7\u79d1\u5b66\u6559\u6388 Haywood Brown \u4e5f\u5f3a\u8c03\uff1a\u201c\u53d7\u5b55\u524d3-6\u4e2a\u6708\u7684\u5065\u5eb7\u5bf9\u5b69\u5b50\u6765\u8bf4\u5f88\u91cd\u8981\uff0c\u4f60\u8981\u786e\u4fdd\u90a3\u6bb5\u65f6\u95f4\u4f60\u8eab\u5f3a\u4f53\u5065\u3002\u80a5\u80d6\u7537\u6027\u7684\u7cbe\u5b50\u6570\u91cf\u66f4\u5c11\uff0c\u800c\u6bcd\u4eb2\u80a5\u80d6\u662f\u5a74\u513f\u60a3\u6709\u51fa\u751f\u7f3a\u9677\uff0c\u6bd4\u5982\u5148\u5929\u5fc3\u810f\u75c5\u7684\u9ad8\u5371\u56e0\u7d20\u3002\u201d<\/p>\n \u6b64\u5916\uff0c\u72b9\u4ed6\u5927\u5b66\u533b\u5b66\u9662\u7684 Kirtly Jones \u751f\u6b96\u533b\u5b66\u6559\u6388\u8868\u793a\uff0c\u5bf9\u7236\u4eb2\u60a3\u6709\u80a5\u80d6\u75c7\u7684\u5b69\u5b50\u7684\u8110\u5e26\u8840\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u5b69\u5b50\u7684\u63a7\u5236\u751f\u957f\u548c\u9499\u7684\u4f7f\u7528\u7684\u4e00\u4e2a\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u53d1\u751f\u4e86\u53d8\u5316\uff0c\u8fd9\u5c06\u5f71\u54cd\u4ed6\u4eec\u672a\u6765\u7684\u53d1\u80b2\u3002<\/p>\n Jones \u4ecb\u7ecd\uff0c\u8fd9\u4e9b\u5e74\u8fd8\u6709\u9488\u5bf9\u80a5\u80d6\u75c7\u7537\u6027\u5728\u51cf\u80a5\u624b\u672f\u524d\u540e\u7684\u7cbe\u5b50\u53d1\u751f\u7684\u53d8\u5316\u7684\u7814\u7a76\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u51cf\u80a5\u624b\u672f\u5bf9\u7cbe\u5b50\u7684\u8868\u89c2\u9057\u4f20\u8d77\u5230\u4e86\u5f88\u5927\u7684\u5f71\u54cd\u3002<\/strong><\/p>\n \u6bd4\u5982\uff0c\u4e39\u9ea6\u54e5\u672c\u54c8\u6839\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u8005\u66fe\u5bf913\u4e2a\u6e05\u7626\u7684\u7537\u6027\u548c10\u4e2a\u80a5\u80d6\u75c7\u7537\u6027\u7684\u7cbe\u5b50\u8fdb\u884c\u4e86\u6bd4\u5bf9\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u4e24\u8005\u63a7\u5236\u540e\u4ee3\u80c3\u53e3\u76f8\u5173\u7684\u8868\u89c2\u9057\u4f20\u6807\u8bb0\u4e0d\u540c\u3002<\/p>\n \u540e\u6765\uff0c\u4ed6\u4eec\u53c8\u6bd4\u5bf9\u4e86\u80c3\u65c1\u8def\u624b\u672f\uff08\u8ba9\u80c3\u4ee5\u4e0d\u540c\u65b9\u5f0f\u91cd\u65b0\u8fde\u63a5\u80a0\u9053\u7684\u51cf\u80a5\u624b\u672f\uff09\u524d\u540e\uff0c\u80a5\u80d6\u75c7\u7537\u6027\u7cbe\u5b50\u7684\u53d8\u5316\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u624b\u672f\u524d\u540e\uff0c\u7cbe\u5b50\u7684 DNA \u5e73\u5747\u53d1\u751f\u4e864000\u4e2a\u7ed3\u6784\u6027\u53d8\u5316\u3002\u8fd9\u9879\u7814\u7a76\u53d1\u8868\u57282015\u5e74\u7684 Cell Metabolism \u4e0a\u3002<\/p>\n \u80c3\u65c1\u8def\u624b\u672f\u793a\u610f\uff08\u5de6\u8fb9\uff09<\/p>\n \u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e4b\u4e00\uff0c\u54e5\u672c\u54c8\u6839\u5927\u5b66\u57fa\u7840\u4ee3\u8c22\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb Romain Barr\u00e8s \u8868\u793a\uff0c\u201c\u6d41\u884c\u75c5\u5b66\u65e9\u5c31\u89c2\u5bdf\u5230\u4e86\u6025\u6027\u8425\u517b\u5e94\u6fc0\uff0c\u6bd4\u5982\u9965\u8352\u5bf9\u540e\u4ee3\u7cd6\u5c3f\u75c5\u60a3\u75c5\u7387\u7684\u5f71\u54cd\u3002\u201d\u4f8b\u5982\uff0c\u745e\u5178\u67d0\u4e2a\u6751\u5e84\u5728\u53d1\u751f\u9965\u8352\u540e\uff0c\u7b2c\u4e09\u4ee3\u4eba\u60a3\u6709\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u7684\u53ef\u80fd\u6027\u663e\u8457\u589e\u52a0\u3002<\/p>\n \u8fd9\u79cd\u53d8\u5316\u53ef\u80fd\u662f\u8868\u89c2\u9057\u4f20\u5b66\u53d8\u5316\uff08\u5982DNA\u7532\u57fa\u5316\uff0c\u6216\u5c0fRNA\uff09\u5e26\u6765\u7684\u3002Barr\u00e8s \u8bf4\uff1a\u201c\u6211\u4eec\u6ca1\u6599\u5230\u4f1a\u53d1\u73b0\u73af\u5883\u538b\u529b\u6709\u8fd9\u4e48\u5927\u7684\u8868\u89c2\u9057\u4f20\u5f71\u54cd\u3002\u751f\u6d3b\u65b9\u5f0f\u548c\u73af\u5883\u56e0\u7d20\u4f1a\u5f71\u54cd\u4e0b\u4e00\u4ee3\u7684\u996e\u98df\u3002\u201d<\/p>\n \u538b\u529b\u5f71\u54cd\u7684\u4e0d\u4ec5\u662f\u7236\u4eb2<\/strong><\/p>\n \u6709\u610f\u601d\u7684\u662f\uff0c\u4e00\u4e9b\u52a8\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u7236\u4eb2\u5728\u6bcd\u4eb2\u53d7\u5b55\u524d\u7684\u7cbe\u795e\u72b6\u6001\uff0c\u4e5f\u4f1a\u5199\u5230\u5b83\u7684\u7cbe\u5b50\u91cc\u3002<\/p>\n 2013\u5e74\uff0c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u8005\u53d1\u8868\u5728\u300a\u795e\u7ecf\u79d1\u5b66\u6742\u5fd7\u300b\uff08Journal of Neuroscience\uff09\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u538b\u529b\u5c71\u5927\uff08\u5e94\u6fc0\uff09\u7684\u5c0f\u9f20\u7238\u7238\u7684\u7cbe\u5b50\u53d1\u751f\u4e86\u53d8\u5316\uff0c\u5b83\u4eec\u540e\u4ee3\u7684\u5927\u8111\u5e94\u6fc0\u53cd\u5e94\u4e5f\u4e0d\u6b63\u5e38\u3002<\/p>\n \u5c0f\u9f20\u8981\u82b142\u5929\u624d\u80fd\u4ea7\u751f\u7cbe\u5b50\uff0c\u56e0\u6b64\u5728\u8fd942\u5929\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u8ba9\u5c0f\u9f20\u7238\u7238\u795e\u7ecf\u7d27\u5f20\uff0c\u6bd4\u5982\u7ed9\u5b83\u4eec\u95fb\u72d0\u72f8\u7684\u5473\u9053\uff0c\u628a\u5b83\u4eec\u7684\u7a9d\u5f04\u6e7f\uff0c\u628a\u5b83\u4eec\u5173\u5c0f\u7ba1\u5b50\uff0c\u6216\u8005\u5236\u9020\u5947\u602a\u7684\u566a\u97f3\u3002\u5728\u8fd9\u5fc3\u60ca\u80c6\u6218\u768442\u5929\u91cc\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u7238\u7238\u7684\u7cbe\u5b50\u7684 DNA \u672c\u8eab\u6ca1\u6709\u53d1\u751f\u53d8\u5316\uff0c\u4f46\u662f DNA \u7684\u8868\u89c2\u9057\u4f20\u5374\u6539\u53d8\u4e86\uff089\u4e2a\u5c0f\u5206\u5b50RNA\u53d1\u751f\u4e86\u53d8\u5316\uff09\u3002<\/strong><\/p>\n 2015\u5e74\u53d1\u8868\u5728\u300a\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520a\u300b\uff08PNAS\uff09\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4e5f\u8bc1\u660e\u5c0f\u5206\u5b50 RNA \uff08\u5305\u542b22\u4e2a\u6838\u82f7\u9178\u7684RNA\uff09\u662f\u8bb0\u5f55\u7238\u7238\u538b\u529b\u7684\u8f7d\u4f53\uff0c\u5c0f\u9f20\u7238\u7238\u5982\u679c\u538b\u529b\u5f88\u5927\uff0c\u90a3\u4e48\u5c0f\u9f20\u5317\u9f3b\u4e5f\u4f1a\u9057\u4f20\u7238\u7238\u7684\u538b\u529b\uff0c\u8868\u73b0\u51fa\u7c7b\u4f3c\u7684\u884c\u4e3a\u3002<\/p>\n \u56e0\u6b64\uff0c\u90a3\u4e9b996\u7684\u5907\u5b55\u7238\u7238\u4eec\uff0c\u8981\u6ce8\u610f\u51cf\u538b\u4e86\u3002\u9700\u8981\u505a\u5907\u5b55\u51c6\u5907\u7684\uff0c\u4e0d\u4ec5\u662f\u5988\u5988\u4eec\u30022018\u5e744\u6708\u53d1\u8868\u5728\u300a\u67f3\u53f6\u5200\u300b\uff08Lancet\uff09\u4e0a\u76843\u9879\u7efc\u8ff0\u6027\u7814\u7a76\u66f4\u540c\u65f6\u628a\u5251\u6307\u5411\u4e86\u5907\u5b55\u671f\u7684\u7238\u7238\u4eec\u3002<\/p>\n \u8fd9\u4e09\u9879\u7814\u7a76\u6307\u51fa\uff0c\u7236\u4eb2\u5728\u914d\u5076\u53d7\u5b55\u524d\u7684\u5065\u5eb7\u72b6\u6001\u4f1a\u5f71\u54cd\u914d\u5076\u7684\u5b55\u671f\u5065\u5eb7\u4ee5\u53ca\u5b69\u5b50\u7684\u5065\u5eb7\uff0c\u6bd4\u5982\u51fa\u751f\u65f6\u7684\u4f53\u91cd\u3001\u65b0\u9648\u4ee3\u8c22\u3001\u514d\u75ab\u7cfb\u7edf\u4ee5\u53ca\u795e\u7ecf\u7cfb\u7edf\u65b9\u9762\u7684\u957f\u671f\u53d1\u80b2\u3002<\/p>\n \u7b2c\u4e8c\u9879\u7814\u7a76\u4e2d\u5199\u9053\uff1a\u5907\u5b55\u671f\u201c\u7236\u6bcd\u7684\u4e0d\u826f\u5065\u5eb7\u72b6\u51b5\u3001\u4e0d\u826f\u4ee3\u8c22\u548c\u996e\u98df\u4e60\u60ef\u4f1a\u589e\u52a0\u540e\u4ee3\u60a3\u6709\u6162\u6027\u75be\u75c5\u7684\u53ef\u80fd\u6027\u3002\u201d<\/p>\n \u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u513f\u79d1\u5b66\u6559\u6388 Milton Kotelchuck 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